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The goal is to increase the sensitivity of the test for younger men more likely to die of the disease and to reduce the frequency of detecting cancers of low malignant potential in elderly men more likely to die of other causes. The 4Kscore test measures 4 prostate-specific kallikreins. The results are combined with clinical information in an algorithm that estimates an individual's percent risk for aggressive prostate cancer should that individual opt for a prostate biopsy.

These 3 tests are combined in a formula that calculates the PHI score. A pathway with imaging to decide which men with an elevated PSA go on to biopsy should reduce unnecessary biopsy and improve diagnostic accuracy. There is some evidence that multiparametric prostate magnetic resonance imaging MRI tends to detect higher risk disease and systematically overlooks low-risk disease, which makes it attractive as a potential triage test. Whether or not this will become standard-of-care is yet to be determined.

Is Prostate Cancer Screening Right for Me?

Concerns regarding the availability of appropriate equipment, availability of expert radiologists, and patient inconvenience relative to a blood test like the 4Kscore Test or PHI may limit the broad use of MRI in this setting. A diagnosis of cancer is established by an image-guided usually transrectal ultrasound-guided needle biopsy. Contemporary schemas advise an extended-pattern core biopsy that includes sampling from the peripheral zone as well as a lesion-directed palpable nodule or suspicious image-guided sampling. National Center for Biotechnology Information , U. Journal List Investig Clin Urol v.

Investig Clin Urol. Published online Jun James Eastham.


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Find articles by James Eastham. Author information Copyright and License information Disclaimer. Corresponding author.

American Cancer Society Recommendations for Prostate Cancer Early Detection

Corresponding Author: James Eastham. CCKSM jmahtsae. This article has been cited by other articles in PMC. References 1. Cancer statistics, CA Cancer J Clin. Familial prostate cancer.

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Semin Oncol. Eur Urol. Cancer Causes Control. Proliferative inflammatory atrophy of the prostate: implications for prostatic carcinogenesis. About the size of a satsuma, it's located between the penis and the bladder, and surrounds the urethra. The main function of the prostate is to produce a thick white fluid that creates semen when mixed with the sperm produced by the testicles.

The causes of prostate cancer are largely unknown. But certain things can increase your risk of developing the condition. The chances of developing prostate cancer increase as you get older. Most cases develop in men aged 50 or older.

Screening | Prostate cancer | Cancer Research UK

For reasons not yet understood, prostate cancer is more common in men of African-Caribbean or African descent, and less common in Asian men. Men whose father or brother were affected by prostate cancer are at slightly increased risk themselves. All the tests used to help diagnose the condition have benefits and risks that your doctor should discuss with you.

Find out more about how prostate cancer is diagnosed. The blood test, called a prostate-specific antigen PSA test, measures the level of PSA and may help detect early prostate cancer.

Prostate cancer detection

Men are not routinely offered PSA tests to screen for prostate cancer, as results can be unreliable. Raised PSA levels also cannot tell a doctor whether a man has life-threatening prostate cancer or not. If you have a raised PSA level, you may be offered an MRI scan of the prostate to help doctors decide if you need further tests and treatment. If the cancer is at an early stage and not causing symptoms, your doctor may suggest either "watchful waiting" or "active surveillance".

The best option depends on your age and overall health.


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  • A PSA test can help catch the disease at an early stage when treatment is thought to be more effective and potentially has fewer side effects. What does PSA Mean? PSA, or prostate specific antigen, is a protein produced by the prostate and found mostly in semen, with very small amounts released into the bloodstream. Rising PSA eventually reaches a level where it can be easily detected by a blood test.

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    What is the PSA Test? During a PSA test, a small amount of blood is drawn from the arm, and the level of PSA, a protein produced by the prostate not prostrate , is measured.

    What is screening?

    Normal PSA ranges can vary according to factors unique to each man, so the PSA test is just a part of the process of screening for prostate cancer. Doctors look at the overall PSA numbers, as well as the rate at which it rises over time and repeated tests velocity.