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Oxford Academic. Google Scholar. Bhanu P Telugu. Loren P Thompson. Cite Citation. Permissions Icon Permissions. Abstract Placental hypoxia can stimulate oxidative stress and mitochondrial dysfunction reducing placental efficiency and inducing fetal growth restriction FGR. Issue Section:. You do not currently have access to this article. Download all figures. Sign in. You could not be signed in. Sign In Forgot password?

Don't have an account? Sign in via your Institution Sign in. Purchase Subscription prices and ordering Short-term Access To purchase short term access, please sign in to your Oxford Academic account above. This article is also available for rental through DeepDyve. View Metrics. Email alerts New issue alert. Advance article alerts. Article activity alert. Subject alert. Maternal nutrient restriction in guinea pigs as an animal model for inducing fetal growth restriction. Maternal nutrient restriction in guinea pigs leads to fetal growth restriction with evidence for chronic hypoxia.

Elmes, M. Fetal exposure to a maternal low-protein diet is associated with altered left ventricular pressure response to ischaemia-reperfusion injury.

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Prenatal diet determines susceptibility to cardiac ischaemia-reperfusion injury following treatment with diethylmaleic acid and N-acetylcysteine. Life Sci. Sex differences in sensitivity to beta-adrenergic agonist isoproterenol in the isolated adult rat heart following prenatal protein restriction. Eriksson, J. Mother's body size and placental size predict coronary heart disease in men. Heart J.

Evans, L. Chronic hypoxia increases peroxynitrite, MMP9 expression, and collagen accumulation in fetal guinea pig hearts. Differential effect of intrauterine hypoxia on caspase 3 and DNA fragmentation in fetal guinea pig hearts and brains. Feng, X. Cortisol stimulates proliferation and apoptosis in the late gestation fetal heart: differential effects of mineralocorticoid and glucocorticoid receptors. Fernandez-Twinn, D. The maternal endocrine environment in the low-protein model of intra-uterine growth restriction. Maternal low-protein diet programs cardiac beta-adrenergic response and signaling in 3-mo-old male offspring.

Exercise rescues obese mothers' insulin sensitivity, placental hypoxia and male offspring insulin sensitivity. Firulli, A. Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1. Fischer, A. The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. Genes Dev. Fishman, N. Models of congenital heart disease in fetal lambs. Circulation 58, — Forhead, A. Thyroid hormones in fetal growth and prepartum maturation.

Fowden, A. Glucocorticoids as regulatory signals during intrauterine development. Galabova-Kovacs, G. Galan, H. Fetal hypertension and abnormal Doppler velocimetry in an ovine model of intrauterine growth restriction. Gao, H. Maternal protein restriction regulates IGF2 system in placental labyrinth. Maternal protein restriction reduces expression of angiotensin I-converting enzyme 2 in rat placental labyrinth zone in late pregnancy.

Gestational protein restriction reduces expression of Hsd17b2 in rat placental labyrinth. Gestational protein restriction affects trophoblast differentiation. Gardner, D. Maintenance of maternal diet-induced hypertension in the rat is dependent on glucocorticoids. Hypertension 30, — Gessler, M. Giraud, G. Cortisol stimulates cell cycle activity in the cardiomyocytes of the fetal sheep. Giussani, D. Developmental programming of cardiovascular dysfunction by prenatal hypoxia and oxidative stress.

Gray, C. Maternal salt and fat intake causes hypertension and sustained endothelial dysfunction in fetal, weanling and adult male resistance vessels. Gurtner, G. Hagen, A. Placental expression of angiopoietin-1, angiopoietin-2 and tie-2 during placental development in an ovine model of placental insufficiency-fetal growth restriction. Harding, J. Studies on experimental growth retardation in sheep. The effects of a small placenta in restricting transport to and growth of the fetus.

Harrison, M. Intergenerational programming of impaired nephrogenesis and hypertension in rats following maternal protein restriction during pregnancy. Hatano, N. Essential role for ERK2 mitogen-activated protein kinase in placental development. Genes Cells 8, — Hoppe, C. Combined prenatal and postnatal protein restriction influences adult kidney structure, function, and arterial pressure. Itoh, M. Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation.

Itoh, S. Vasodilation to vascular endothelial growth factor in the uterine artery of the pregnant rat is blunted by low dietary protein intake. Jackson, A. Increased systolic blood pressure in rats induced by a maternal low-protein diet is reversed by dietary supplementation with glycine. Jelks, A. Paradoxical increase in maternal plasma leptin levels in food-restricted gestation: contribution by placental and adipose tissue.

Jones, C. Studies on the growth of the fetal guinea pig. Changes in plasma hormone concentration during normal and abnormal growth. Studies on the growth of the fetal sheep. Effects of surgical reduction in placental size, or experimental manipulation of uterine blood flow on plasma sulphation promoting activity and on the concentration of insulin-like growth factors I and II.

Jonker, S. Sequential growth of fetal sheep cardiac myocytes in response to simultaneous arterial and venous hypertension. Myocyte enlargement, differentiation, and proliferation kinetics in the fetal sheep heart. Kajstura, J. Cell Res. Kane, A. Vitamin C prevents intrauterine programming of in vivo cardiovascular dysfunction in the rat.

Kastner, P. Cell 78, — Khorram, O. Nutrient restriction in utero induces remodeling of the vascular extracellular matrix in rat offspring. In utero undernutrition in rats induces increased vascular smooth muscle content in the offspring. Maternal undernutrition inhibits angiogenesis in the offspring: a potential mechanism of programmed hypertension. Effect of maternal undernutrition on vascular expression of micro and messenger RNA in newborn and aging offspring. Kim, H. Human fetal heart development after mid-term: morphometry and ultrastructural study.

Koumentaki, A. Low-protein diet impairs vascular relaxation in virgin and pregnant rats. Kulandavelu, S. Endothelial NO synthase augments fetoplacental blood flow, placental vascularization, and fetal growth in mice. Hypertension 61, — Kwee, L. Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule VCAM-1 deficient mice. Development , — Lafeber, H. The effects of ligation of the uterine artery on organ growth and development. Langley, S. Increased systolic blood pressure in adult rats induced by fetal exposure to maternal low protein diets.

Langley-Evans, S. Captopril normalises systolic blood pressure in rats with hypertension induced by fetal exposure to maternal low protein diets. Impaired growth and increased glucocorticoid-sensitive enzyme activities in tissues of rat fetuses exposed to maternal low protein diets. In utero exposure to maternal low protein diets induces hypertension in weanling rats, independently of maternal blood pressure changes. Protein intake in pregnancy, placental glucocorticoid metabolism and the programming of hypertension in the rat.

Placenta 17, — Hypertension induced by foetal exposure to a maternal low-protein diet, in the rat, is prevented by pharmacological blockade of maternal glucocorticoid synthesis. Hypertension 15, — Maternal carbenoxolone treatment lowers birthweight and induces hypertension in the offspring of rats fed a protein-replete diet. Lebowitz, E. Development of myocardial sympathetic innervation in the fetal lamb. Lesage, J. Maternal undernutrition during late gestation induces fetal overexposure to glucocorticoids and intrauterine growth retardation, and disturbs the hypothalamo-pituitary adrenal axis in the newborn rat.

Maternal undernutrition during late gestation-induced intrauterine growth restriction in the rat is associated with impaired placental GLUT3 expression, but does not correlate with endogenous corticosterone levels. Li, F.

Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development. Li, G. Effect of fetal hypoxia on heart susceptibility to ischemia and reperfusion injury in the adult rat. Effect of prenatal hypoxia on heat stress-mediated cardioprotection in adult rat heart. Liang, C. Birth Defects Res. B Dev. Reprod Toxicol. Lim, K. Effect of maternal protein restriction during pregnancy and lactation on the number of cardiomyocytes in the postproliferative weanling rat heart. Limesand, S. Characterization of glucose transporter 8 GLUT8 in the ovine placenta of normal and growth restricted fetuses.

Placenta 25, 70— Attenuated insulin release and storage in fetal sheep pancreatic islets with intrauterine growth restriction. Linask, K. Changes in vitelline and utero-placental hemodynamics: implications for cardiovascular development. Lipp, J. Sympathetic nerve development in the rat and guinea-pig heart. Neonate 21, 76— Liu, X. Maternal protein restriction alters VEGF signaling and decreases pulmonary alveolar in fetal rats. Llanos, A. Increased heart rate response to parasympathetic and beta adrenergic blockade in growth-retarded fetal lambs. Lopes Floro, K. Loss of Cited2 causes congenital heart disease by perturbing left-right patterning of the body axis.

Louey, S. Placental insufficiency and fetal growth restriction lead to postnatal hypotension and altered postnatal growth in sheep. Placental insufficiency decreases cell cycle activity and terminal maturation in fetal sheep cardiomyocytes. Lumbers, E. Effects of cortisol on cardiac myocytes and on the expression of cardiac genes in fetal sheep. Effects of intrafetal IGF-I on growth of cardiac myocytes in late-gestation fetal sheep.

Martyn, C. Mothers' pelvic size, fetal growth, and death from stroke and coronary heart disease in men in the UK. Lancet , — Maruyama, E. Extraembryonic but not embryonic SUMO-specific protease 2 is required for heart development. Mascrez, B. A transcriptionally silent RXRalpha supports early embryonic morphogenesis and heart development. Mayeur, S. Placenta 31, — Maternal calorie restriction modulates placental mitochondrial biogenesis and bioenergetic efficiency: putative involvement in fetoplacental growth defects in rats.

Apelin controls fetal and neonatal glucose homeostasis and is altered by maternal undernutrition. Diabetes 65, — Mess, A. Caviomorph placentation as a model for trophoblast invasion. Placenta 28, — The Guinea pig placenta: model of placental growth dynamics. Miller, S. The effects of sildenafil citrate Viagra on uterine blood flow and well being in the intrauterine growth-restricted fetus. Cardiovascular responses to maternal betamethasone administration in the intrauterine growth-restricted ovine fetus.

Monson, T. Caspase dependent and independent mechanisms of apoptosis across gestation in a sheep model of placental insufficiency and intrauterine growth restriction. Apoptosis 22, — Moreau, J. Cited2 is required in trophoblasts for correct placental capillary patterning. Mori, A. Haemodynamic changes in IUGR fetus with chronic hypoxia evaluated by fetal heart-rate monitoring and Doppler measurement of blood flow velocity.

Morrison, J. Restriction of placental function alters heart development in the sheep fetus. Sheep models of intrauterine growth restriction: fetal adaptations and consequences. Morton, J. Mechanisms of endothelium-dependent vasodilation in male and female, young and aged offspring born growth restricted. Mudgett, J. Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis. Murotsuki, J. Chronic fetal placental embolization and hypoxemia cause hypertension and myocardial hypertrophy in fetal sheep.

Musha, Y. Does estrogen affect the development of abnormal vascular function in offspring of rats fed a low-protein diet in pregnancy? Myatt, L. Placental adaptive responses and fetal programming. Nascimento, L. The effect of maternal low-protein diet on the heart of adult offspring: role of mitochondria and oxidative stress. Nevin, C. Maternal nutrient restriction in guinea pigs as an animal model for studying growth restricted offspring with post-natal catch-up growth. Oh, W. Umbilical blood flow and glucose uptake in lamb fetus following single umbilical artery ligation.

Neonate 26, — O'Tierney, P. Reduced systolic pressure load decreases cell-cycle activity in the fetal sheep heart. Ouseph, M. Atypical E2F repressors and activators coordinate placental development. Cell 22, — Owens, J. Effect of restriction of placental growth on fetal and utero-placental metabolism. Glucose metabolism in pregnant sheep when placental growth is restricted.

Oyama, K. Single umbilical artery ligation-induced fetal growth retardation: effect on postnatal adaptation. Paradis, A. Endothelin-1 promotes cardiomyocyte terminal differentiation in the developing heart via heightened DNA methylation. Paulino-Silva, K. Hypertension in rat offspring subjected to perinatal protein malnutrition is not related to the baroreflex dysfunction. Phillips, I. Placental restriction alters the functional development of the pituitary-adrenal axis in the sheep fetus during late gestation. Restriction of fetal growth has a differential impact on fetal prolactin and prolactin receptor mRNA expression.

Phillips, T. Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development. Poudel, R. Impact of chronic hypoxemia on blood flow to the brain, heart, and adrenal gland in the late-gestation IUGR sheep fetus. Raffel, G. Ott1 Rbm15 is essential for placental vascular branching morphogenesis and embryonic development of the heart and spleen.

Rebelato, H. Gestational protein restriction induces alterations in placental morphology and mitochondrial function in rats during late pregnancy.

Transfer of hydrophilic molecules by placenta and yolk sac of the guinea pig

Gestational protein restriction alters cell proliferation in rat placenta. Regan, C. Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects. Regnault, T. Altered arterial concentrations of placental hormones during maximal placental growth in a model of placental insufficiency. The relationship between transplacental O 2 diffusion and placental expression of PlGF, VEGF and their receptors in a placental insufficiency model of fetal growth restriction.

Development and mechanisms of fetal hypoxia in severe fetal growth restriction. Umbilical uptakes and transplacental concentration ratios of amino acids in severe fetal growth restriction. Rennie, M. Effects of genes and environment on the fetoplacental arterial microcirculation in mice revealed by micro-computed tomography imaging. Microcirculation 21, 48— Reynolds, C. Richter, H.

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Ascorbate prevents placental oxidative stress and enhances birth weight in hypoxic pregnancy in rats. Riley, P. The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis. Riviere, G. Angiotensin-converting enzyme 2 ACE2 and ACE activities display tissue-specific sensitivity to undernutrition-programmed hypertension in the adult rat. Hypertension 46, — Roberts, C. Maternal food restriction reduces the exchange surface area and increases the barrier thickness of the placenta in the guinea-pig. Placenta 22, — Placenta 22 Suppl. A , S77—S Placenta 23, — Robinson, J.

The effect of removal of a endometrial caruncles on fetal size and metabolism. Roseboom, T. The Dutch famine and its long-tem consequences for adult health. Early Hum. Rossini, K. Gestational protein restriction increases cardiac connexin 43 mRNA levels in male adult rat offspring. Rudolph, A. Perinatal myocardial DNA and protein changes in the lamb: effect of cortisol in the fetus. Rueda-Clausen, C. Effects of hypoxia-induced intrauterine growth restriction on cardiopulmonary structure and function during adulthood. Effects of hypoxia-induced intrauterine growth restriction on cardiac siderosis and oxidative stress.

Health Dis. Rutland, C. Effect of gestational nutrition on vascular integrity in the murine placenta. Samuel, J. Is cardiac hypertrophy a required compemsatory mechanism in pressure-pverloaded heart? J Hypertension 26, — Sapin, V. Differential expression of transcripts encoding retinoid binding proteins and retinoic acid receptors during placentation of the mouse. Sathishkumar, K. Protein restriction during pregnancy induces hypertension and impairs endothelium-dependent vascular function in adult female offspring.

Protein restriction during pregnancy induces hypertension in adult female rat offspring—influence of oestradiol. Enhanced mesenteric arterial responsiveness to angiotensin II is androgen receptor-dependent in prenatally protein-restricted adult female rat offspring. Reprod Scheffen, I. Alterations of the fetal capillary bed in the guinea pig placenta following long-term hypoxia. Schorpp-Kistner, M. JunB is essential for mammalian placentation.

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EMBO J. Schreiber, M. Placental vascularisation requires the AP-1 component fra1. Scotti, M.

Guinea pig Placenta-E35 Total RNA

Recruitment of 5' Hoxa genes in the allantois is essential for proper extra-embryonic function in placental mammals. Segar, J. Angiotensin AT1 receptor blockade fails to attenuate pressure-overload cardiac hypertrophy in fetal sheep. Sferruzzi-Perri, A. The programming power of the placenta. An obesogenic diet during mouse pregnancy modifies maternal nutrient partitioning and the fetal growth trajectory.

FASEB 27, — Shah, A. Cardiovascular susceptibility to in vivo ischemic myocardial injury in male and female rat offspring exposed to prenatal hypoxia. Shaut, C. HOXA13 is essential for placental vascular patterning and labyrinth endothelial specification.

PLoS Genet. Sherman, R. Antihypertensive treatment in early postnatal life modulates prenatal dietary influences upon blood pressure in the rat. Simonetta, G. Impact of placental restriction on the development of the sympathoadrenal system. Slater-Jefferies, J. Feeding a protein-restricted diet during pregnancy induces altered epigenetic regulation of peroxisomal proliferator-activated receptor-alpha in the heart of the offspring. Snoeck, A. Effect of a low protein diet during pregnancy on the fetal rat endocrine pancreas.

Neonate 57, — Sohlstrom, A. Soonpaa, M. Cardiomyocyte DNA synthesis and binucleation during murine development. Strakovsky, R. A low-protein diet during gestation in rats activates the placental mammalian amino acid response pathway and programs the growth capacity of offspring. Stumpo, D. Chorioallantoic fusion defects and embryonic lethality resulting from disruption of Zfp36L1, a gene encoding a CCCH tandem zinc finger protein of the Tristetraprolin family.

Sundgren, N. Extracellular signal-regulated kinase and phosphoinositol-3 kinase mediate IGF-1 induced proliferation of fetal sheep cardiomyocytes. Supramaniam, V. Chronic fetal hypoxia increases activin A concentrations in the late-pregnant sheep. Szabova, L. Membrane-type MMPs are indispensable for placental labyrinth formation and development. Blood , — Tai-Nagara, I. Takeda, K. Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2. Tanaka, H. Hepatocyte growth factor activator inhibitor type 1 HAI-1 is required for branching morphogenesis in the chorioallantoic placenta.

Tare, M. Maternal melatonin administration mitigates coronary stiffness and endothelial dysfunction, and improves heart resilience to insult in growth restricted lambs. Thompson, L. Chronic hypoxia decreases endothelial nitric oxide synthase protein expression in fetal guinea pig hearts. Thompson, R. Doppler waveform pulsatility index and resistance, pressure and flow in the umbilical placental circulation: an investigation using a mathematical model. Chronic hypoxia inhibits contraction of fetal arteries by increased endothelium-derived nitric oxide and prostaglandin synthesis.

Chronic hypoxia increases inducible NOS-derived nitric oxide in fetal guinea pig hearts. Thompson, J. Chronic intrauterine hypoxia interferes with aortic development in the late gestation ovine fetus. Increased collagen deposition in the heart of chronically hypoxic ovine fetuses. Placental hypoxia during early pregnancy causes maternal hypertension and placental insufficiency in the hypoxic guinea pig model. Thureen, P. Placental glucose transport in heat-induced fetal growth retardation.

Tong, W. Maternal hypoxia alters matrix metalloproteinase expression patterns and causes cardiac remodeling in fetal and neonatal rats. Torrens, C. Maternal protein restriction in the rat impairs resistance artery but not conduit artery function in pregnant offspring. Folate supplementation during pregnancy improves offspring cardiovascular dysfunction induced by protein restriction. Hypertension 47, — Transmission of raised blood pressure and endothelial dysfunction to the F2 generation induced by maternal protein restriction in the F0, in the absence of dietary challenge in the F1 generation.

Trudinger, B. Fetal umbilical artery flow velocity waveforms and placental resistance: clinical significance. Umbilical artery flow velocity waveforms and placental resistance: the effects of embolization of the umbilical circulation. Tucker, D. Components of functional sympathetic control of heart rate in neonatal rats.

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Unezaki, S. Genes Cells 12, — Vickers, M. Fetal origins of hyperphagia, obesity, and hypertension and postnatal amplification by hypercaloric nutrition. Adult growth hormone treatment reduces hypertension and obesity induced by an adverse prenatal environment. Vranas, S. Small size at birth predicts decreased cardiomyocyte number in the adult ovine heart. Wadley, G. Growth restriction before and after birth increases kinase signaling pathways in the adult rat heart.

Growth restriction in the rat alters expression of metabolic genes during postnatal cardiac development in a sex-specific manner. Genomics 45, 99— Endurance training in early life results in long-term programming of heart mass in rats. Wakefield, S. Impaired mitochondrial function in the preimplantation embryo perturbs fetal and placental development in the mouse.

Walker, D. Effect of hyperthermia on the plasma concentrations of prolactin and cortisol in the fetal lamb and pregnant ewe during late gestation. Walker, B. Glucocorticoids and cardiovascular disease. Wang, K. Fetal growth restriction and the programming of heart growth and cardiac insulin-like growth factor 2 expression in the lamb. IGF-2R-mediated signaling results in hypertrophy of cultured cardiomyocytes from fetal sheep.


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Alteration of cardiac glucose metabolism in association to low birth weight: experimental evidence in lambs with left ventricular hypertrophy. Low birth weight activates the renin-angiotensin system, but limits cardiac angiogenesis in early postnatal life. IGF-2R-Galphaq signaling and cardiac hypertrophy in the low-birth-weight lamb.

Watkins, A. Adaptive responses by mouse early embryos to maternal diet protect fetal growth but predispose to adult onset disease. Maternal periconceptional and gestational low protein diet affects mouse offspring growth, cardiovascular and adipose phenotype at 1 year of age. PloS One 6:e Maternal nutrition modifies trophoblast giant cell phenotype and fetal growth in mice.