e-book Endothelial Cells in Health and Disease

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Endothelial Cells in Health and Disease

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Microvascular Endothelial Cell Function in Health and Disease Linked to MMPs and TIMPs

No Downloads. Views Total views. Malignant pleural mesothelioma MPM is an aggressive tumor that develops in the pleura, which are the membranes that surround and encase the lungs. MPM has a poor prognosis and therefore, development of better therapeutic options is critical. Tumor angiogenesis is also driven by the plasminogen activation system, which includes plasminogen activator inhibitor-1 PAI In a study, using in vivo and in vitro models of MPM, Takayama and colleagues investigated whether inhibition of PAI-1 using SK a PAIspecific inhibitor could have anti-tumor effects, irrespective of the angiogenesis stimulus.

To confirm that SK was acting by decreasing tumor angiogenesis, the authors examined microvessel density using immunohistochemistry for CD31 and found that SKtreated tumors derived from both cell lines had decreased angiogenesis as expected.

The Vascular Endothelium and Human Diseases

Next, the researchers used in vitro proliferation assays to demonstrate that SK does not affect the proliferation of EHMES or MSTOH cells alone, but does synergize with cisplatin, a chemotherapy drug that blocks cell proliferation, to reduce tumor weight and prolong survival in vivo. Together, the results of this study illustrate that SK negatively affects MPM tumor progression independent of the pro-angiogenic stimulus, and PAI-1 is therefore a good therapeutic target for MPM treatment.

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Endothelial Cells: Research in Cardiovascular Disease and Mesothelioma In Endothelial Cells Endothelial Cells: Regulators of Vessel Homeostasis and Angiogenesis Endothelial cells line the blood vessels of the circulatory system and play major roles in cardiovascular homeostasis. Search for:.