You can change your ad preferences anytime. Upcoming SlideShare. Like this presentation? Why not share! Vascular Endothelium in Health and Embed Size px. Start on. Show related SlideShares at end.
About this Research Topic
WordPress Shortcode. Sweety Kalantri Follow. Full Name Comment goes here.
- Two Books of the Elements of Universal Jurisprudence (Natural Law and Enlightenment Classics)!
- Immunology For Life Scientists.
- role of endothelial glycocalyx in health and disease | Clinical Kidney Journal | Oxford Academic.
- Contact Info?
Are you sure you want to Yes No. Harsha Shrivastava. Arthi Anand. Show More.
Microvascular Endothelial Cell Function in Health and Disease Linked to MMPs and TIMPs
No Downloads. Views Total views. Malignant pleural mesothelioma MPM is an aggressive tumor that develops in the pleura, which are the membranes that surround and encase the lungs. MPM has a poor prognosis and therefore, development of better therapeutic options is critical. Tumor angiogenesis is also driven by the plasminogen activation system, which includes plasminogen activator inhibitor-1 PAI In a study, using in vivo and in vitro models of MPM, Takayama and colleagues investigated whether inhibition of PAI-1 using SK a PAIspecific inhibitor could have anti-tumor effects, irrespective of the angiogenesis stimulus.
To confirm that SK was acting by decreasing tumor angiogenesis, the authors examined microvessel density using immunohistochemistry for CD31 and found that SKtreated tumors derived from both cell lines had decreased angiogenesis as expected.
The Vascular Endothelium and Human Diseases
Next, the researchers used in vitro proliferation assays to demonstrate that SK does not affect the proliferation of EHMES or MSTOH cells alone, but does synergize with cisplatin, a chemotherapy drug that blocks cell proliferation, to reduce tumor weight and prolong survival in vivo. Together, the results of this study illustrate that SK negatively affects MPM tumor progression independent of the pro-angiogenic stimulus, and PAI-1 is therefore a good therapeutic target for MPM treatment.
Share your experiences and model systems with us, and it could be featured on the blog! Check in with us here every other week for a rundown of new research from around the world. Loading cart contents View Cart Checkout Cart subtotal: ….
Learn More. Valid for U.
- Endothelial Cell Phenotypes in Health and Disease Conference GRC.
- Tumor Suppressor Genes in Human Cancer (Cancer Drug Discovery and Development).
- 1st Edition.
Endothelial Cells: Research in Cardiovascular Disease and Mesothelioma In Endothelial Cells Endothelial Cells: Regulators of Vessel Homeostasis and Angiogenesis Endothelial cells line the blood vessels of the circulatory system and play major roles in cardiovascular homeostasis. Search for:.