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Charbon is a distinguished visiting scholar of the W. Myers, University of Utah Abstract - Researchers are now able to engineer synthetic genetic circuits for a range of applications in the environmental, medical, and energy domains. Crucial to the success of these efforts is the development of methods and tools for genetic design automation GDA.

While inspiration can be drawn from experiences with electronic design automation EDA , design with a genetic material poses several challenges. In particular, genetic circuits are composed of very noisy components making their behavior more asynchronous, analog, and stochastic in nature. This talk presents our research in the development of the GDA tool, iBioSim, which leverages our past experiences in asynchronous circuit synthesis and formal verification to address these challenges.

The iBioSim tool enables the synthetic biologist to construct models in a familiar graphical form, analyze them using a variety of methods that leverage efficient abstractions, visualize their analysis results using an intuitive interface, and ultimately synthesize a genetic implementation from a library of genetic parts.

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Each step of this design process utilizes standard data representation formats enabling the ready exchange of results. Chris J. Myers received the B.


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Myers is the author of over technical papers and the textbooks Asynchronous Circuit Design and Engineering Genetic Circuits. He is also a co-inventor on 4 patents.

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Some of the earliest computers were designed without clocks, and commercial applications of asynchronous designs have unremarkably dotted the history of VLSI systems over the past 50 years. The predominant view among technologists today is that asynchronous techniques have rarely, if ever, provided unambiguous value for their applications in a way that would outperform synchronous approaches.

Regardless of the truth of that view, the asynchronous community needs to fundamentally shift its perspectives and practices if asynchronous design methods are ever to become relevant for mainstream use.


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  4. Analog Circuit Design for Process Variation-Resilient Systems-on-a-Chip || - [PDF Document].
  5. In this talk I offer a straw man proposal for how we can rescue asynchronous from the doldrums of VLSI design. Over that time, Fulcrum produced five generations of switch products with leading bandwidth, latency, power, and features.


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    For example, research in the asynchronous community has been exploring purely analog effects such as metastability. Likewise, the effects of electromagnetic noise due to global clocking have been studied as well as cross-talk.

    Program Committee

    In my group we have been recently investigating other new bridges between asynchronous and analog worlds. One of them is the design of what we call 'little digital' electronics which sits inside analog and mixed signal systems and controls the analog parts by switching energy flow in them. DC-DC converters and various kinds of sensors are examples where asynchronous circuits are increasingly more advantageous than their clocked counterparts. For example, they help not only reduce latency of response to events in analog parts, but also ultimately improve physical characteristics of the whole system such as power efficiency, smaller capacitors and inductors.

    However, a major consequence of the drive toward ever smaller transistor gate lengths is an exponential increase in intrawafer and intradie process variations that degrade on circuit performance. Consequently, designers must over-constrain performance order to guarantee sufficient postfabrication performance yield.

    Analog Circuit Design for Process Variation-Resilient Systems-on-a-Chip ||

    The goal of the Self-HEALing Mixed-Signal Integrated Circuits HEALICs program is to regain this lost performance by adding sensing and control circuitry that will compensate for the process, environmental, and ageing variations in situ, which will ultimately allow designers to focus on performance goals and not on yield-related issues. This initiative is not limited to any particular type of circuit or control approach; rather, it aims to develop techniques and technologies that allow any mixed-signal design to be runtime-corrected at the SoC level.

    The technologies developed under this program also have the potential to significantly enhance the long-term reliability of DoD electronic systems.

    Stanford Seminar - Electronic Design Automation and the Resurgence of Chip Design

    HEALICs performers will demonstrate their self-healing control algorithms and circuitry on a complex, mixed-signal baseline SoC design that was determined to be impractical due to processing technology variability or was realized with extremely poor near zero performance yield as measured by target performance metrics. The program goals are to demonstrate that, upon the activation of this on-chip healing circuitry, the performance yield of their baseline SoC can be dramatically increased to greater than 95 percent with less than a 5 percent increase in power consumption and low impact on overall chip area.