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This value is comparable to that achieved by the previously reported electrochemical methods Table 1. However, the present method obviates the need of a phosphorylation process and the use of ATP analogs as the cosubstrates as well as the modified nanoparticles for signal amplification, thus reducing the operation complexity and saving assay time. B Dependence of i pa on PKA concentration. The inset shows the linear part of the fitting curve. In order to demonstrate the specificity of the present method for the analysis of PKA, four interfering proteins BSA, tyrosine kinase Src, lysozyme, and thrombin at the concentration of at least fivefold higher than that of PKA were tested.

As shown in Figure 8 , compared to the control, the four interferences did not cause a significant decrease in the current. The result, agreeing with that observed by QCM, 42 indicated that the proposed electrochemical method showed good selectivity to PKA. This work presented a new AuNPs-based strategy for the detection of protein kinase.

Damien W. M. Arrigan (Ed): Electrochemical Strategies in Detection Science - Semantic Scholar

In contrast to the substrate peptide, the aptameric peptide exhibited a much higher binding affinity for the target protein. The AuNPs-based electrochemical method not only features simple manipulation principle and easy detection procedure similar to that of colorimetric assay, but also shows high sensitivity and specificity. Because the charge of kinase-specific peptide probe inhibitor could exactly be tuned by inserting positively or negatively charged amino acid residues and AuNPs in the both positive and negative forms can be easily prepared, 12 , 53 , 54 , 69 it is believed that the present strategy could be used for the detection of other kinases by using the sequence-specific peptide substrates.

Moreover, this proposed detection principle should also be valuable for the development of label-free optical platforms by using multiplexed aptameric peptide microarrays. Datta S, Mukhopadhyay S. An ensemble method approach to investigate kinase-specific phosphorylation sites. Int J Nanomed. Adams JA. Kinetic and catalytic mechanisms of protein kinases. Chem Rev. High-efficiency liposomal encapsulation of a tyrosine kinase inhibitor leads to improved in vivo toxicity and tumor response profile. Dynamics of cAMP-dependent protein kinase. Single-step kinase inhibitor screening using a peptide-modified gold nanoparticle platform.

Chem Commun Camb. Multimodal electrochemical and nanoplasmonic biosensors using ferrocene-crowned nanoparticles for kinase drug discovery applications. Electrochem Commun. Delivery of DNAzyme targeting aurora kinase A to inhibit the proliferation and migration of human prostate cancer. Nanomaterial-based tools for protein kinase bioanalysis. Peptide chips for the quantitative evaluation of protein kinase activity. Nat Biotechnol. Kinase-actuated immunoaggregation of peptide-conjugated gold nanoparticles.

Rapid detection of protein phosphatase activity using Zn II -coordinated gold nanosensors based on His-tagged phosphopeptides. Anal Chem. Colorimetric enzymatic activity assay based on noncrosslinking aggregation of gold nanoparticles induced by adsorption of substrate peptides. Visual and surface plasmon resonance sensor for zirconium based on zirconium-induced aggregation of adenosine triphosphate-stabilized gold nanoparticles.

Label-free Electrochemical Detection of ATP Based on Amino-functionalized Metal-organic Framework

Anal Chim Acta. Phosphorylation-regulated crosslinking of gold nanoparticles: a new strategy for colorimetric detection of protein kinase activity. Kinase-catalyzed modification of gold nanoparticles: a new approach to colorimetric kinase activity screening. J Am Chem Soc.

Enzyme colorimetric assay using unmodified silver nanoparticles. A gold nanoparticles colorimetric assay for label-free detection of protein kinase activity based on phosphorylation protection against exopeptidase cleavage. Biosens Bioelectron. Probing kinase activities by electrochemistry, contact-angle measurements, and molecular-force interactions. Chem Eur J. Electrochemical strategy for detection of phosphorylation based on enzyme-linked electrocatalysis. J Electroanal Chem.

Damien W. M. Arrigan (Ed): Electrochemical Strategies in Detection Science

Sensitive label-free monitoring of protein kinase activity and inhibition using ferric ions coordinated to phosphorylated sites as electrocatalysts. Homogeneous electrochemical assay for protein kinase activity. DNA assembled gold nanoparticles polymeric network blocks modular highly sensitive electrochemical biosensors for protein kinase activity analysis and inhibition. A sensitive electrochemical biosensor for detection of protein kinase A activity and inhibitors based on Phos-tag and enzymatic signal amplification.

TiO 2 -assisted silver enhanced biosensor for kinase activity profiling. Electrochemical strategy for sensing protein phosphorylation.

Bioconjug Chem. Portable and sensitive detection of protein kinase activity by using commercial personal glucose meter. Sens Actuat B-Chem. Gold nanoparticle-based electrochemical detection of protein phosphorylation. Kerman K, Kraatz HB. Electrochemical detection of kinase-catalyzed thiophosphorylation using gold nanoparticles. Peptide biosensors for the electrochemical measurement of protein kinase activity.


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Versatile strategy for biochemical, electrochemical and immunoarray detection of protein phosphorylations. Long-wavelength fluorescent reporters for monitoring protein kinase activity. Angew Chem Int Ed. Label-free fluorescence assay for protein kinase based on peptide biomineralized gold nanoclusters as signal sensing probe. Phosphorylation-directed assembly of a single quantum dot based nanosensor for protein kinase assay.

Using graphene quantum dots as photoluminescent probes for protein kinase sensing. Label-free fluorescent detection of protein kinase activity based on the aggregation behavior of unmodified quantum dots. Phosphorylation-mediated assembly of a semisynthetic fluorescent protein for label-free detection of protein kinase activity. Rare earth ion mediated fluorescence accumulation on a single microbead: an ultrasensitive strategy for the detection of protein kinase activity at the single-cell level.

Design of an encodable tyrosinekinase-inducible domain: detection of tyrosine kinase activity by terbium luminescence.


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Sensitive detection of protein kinase A activity in cell lysates by peptide microarray-based assay. Aptameric peptide for one-step detection of protein kinase. Dye-sensitized and localized surface plasmon resonance enhanced visible-light photoelectrochemical biosensors for highly sensitive analysis of protein kinase activity. Plasmonic ruler on field-effect devices for kinase drug discovery applications. Protein phosphorylation detection using dual-mode field-effect devices and nanoplasmonic sensors. Sci Rep. Peptide aptamers in label-free protein detection: 2.

Chemical optimization and detection of distinct protein isoforms. Multiple signal amplification electrogenerated chemiluminescence biosensors for sensitive protein kinase activity analysis and inhibition. Highly sensitive electrogenerated chemiluminescence biosensor in profiling protein kinase activity and inhibition using gold nanoparticle as signal transduction probes. Ru II encapsulated phosphorylate-terminated silica nanoparticles-based electrochemiluminescent strategy for label-free assay of protein kinase activity and inhibition.

Zirconium—metalloporphyrin frameworks as a three-in-one platform possessing oxygen nanocage, electron media, and bonding site for electrochemiluminescence protein kinase activity assay. Protein kinase assay on peptide-conjugated gold nanoparticles by using secondary-ion mass spectrometric imaging. High-throughput identification of substrate specificity for protein kinase by using an improved one-bead-one-compound library approach.

High-throughput colorimetric detection of tyrosine kinase inhibitors based on the aggregation of gold nanoparticles.

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Anal Biochem. Measurement of homogeneous kinase activity for cell lysates based on the aggregation of gold nanoparticles. Functionalized graphene oxide as a nanocarrier in a multienzyme labeling amplification strategy for ultrasensitive electrochemical immunoassay of phosphorylated p53 S Spotlight on nano-theranostics in South Korea: applications in diagnostics and treatment of diseases. Potential diagnostic applications of biosensors: current and future directions. Sensitive electrochemical immunosensor based on three-dimensional nanostructure gold electrode.

Peptides targeting protein kinases: strategies and implications.

Differential and common recognition of the C sites of the cGMP-dependent and cAMP-dependent protein kineses by inhibitory peptides derived from the heat-stable derived from the heat stable inhibitor protein. J Biol Chem. A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase. Novel graphene-gold nanoparticle modified electrodes for the high sensitivity electrochemical spectroscopy detection and analysis of carbamazepine.

J Phys Chem C. Few-layer graphene sheets with embedded gold nanoparticles for electrochemical analysis of adenine. Chronocoulometric biosensor for K-ras point mutation detection based on E. Brand new Book. Seller Inventory AAJ New Book. Shipped from UK. Established seller since Seller Inventory CA Items related to Electrochemical Strategies in Detection Science. Electrochemical Strategies in Detection Science. Publisher: Royal Society of Chemistry , This specific ISBN edition is currently not available.

Detection Electrochemical in Science Strategies

View all copies of this ISBN edition:. Synopsis About this title Electrochemical methods of chemical analysis have been widely used for many years, most especially the trusty pH electrode and conductivity meter, but also in the mass-manufactured glucose test strips which place electrochemical measurements into the hands of non-scientists. From the Inside Flap : Electrochemical methods of chemical analysis have been widely used for many years, most especially the trusty pH electrode and conductivity meter, but also in the mass-manufactured glucose test strips which place electrochemical measurements into the hands of non-scientists.

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